Saturday, 18 September 2010

Marshall Goldsmith and his workshop

You can listen and try to be a bit relaxed to improve yourself in your working environment and your leadership qualities.Despite his outstanding experience he presents with lucidity and down to earth level.
He is a world authority in helping successful leaders even to get better -- in achieving positive change in behavior for their better change.

Sunday, 12 September 2010

Do you have an obese child ?........ then read the article.

If you are the parent of a obese child, though a modern day syndrome of overfeeding the kid irrespective of the physical activity of the kid, you need to read this below.

With the epidemic of childhood obesity, it is not uncommon for prescribers to puzzle over an appropriate drug dose for an obese child. Defining the optimum therapeutic dose of a drug relies on an understanding of pharmacokinetics and pharmacodynamics. [ don't worry about medical terminologies ]
Both these processes can be affected by body composition and the physiological changes that occur in obese children. As a rule of thumb, 75% of excess weight in obese subjects is fat mass, and the remainder lean mass.
 Although it is reasonable to assume that increases in fat mass alter the distribution of lipophilic drugs [ drugs that dissolves with fat of the baby ]and increases in lean mass alter drug clearance, good quality and consistent clinical data supporting these assumptions are lacking for the majority of drugs. 
The relatively few clinical studies that have evaluated the impact of obesity have often been limited by poor design and insufficient sample size. Moreover, clinical studies conducted during drug development rarely include (or are required to include) obese subjects. Guidance on dosing obese children ought to be provided by drug manufacturers. 
This could be achieved by including obese patients in studies where possible, enabling the effect of body size on pharmacotherapy to be evaluated. This approach could be further augmented by the use of physiologically based-pharmacokinetic models during early (preclinical) development to predict the impact of obesity on drug disposition, and subsequent clinical studies later in development to provide confirmatory proof. 
In the meantime, for the majority of drugs already prescribed in children, particularly those where the therapeutic range is narrow or there is significant toxicity, the lack of a validated body size descriptor to use at the bedside means the choice of dose will rely on empirical experience and application of the precautionary principle.
So whenever your kid being prescribed by a Doc, ask his counselling with regard to dosage and don't be shy in admitting that your kid is fatty or obese.
Please try to make your kid play [ I mean play physically not computer oriented ]    Haaaaaaaaaaaaa..........

Note: meaning of obesity..........very fat or overweight; corpulent.

Saturday, 4 September 2010

How Music training primes nervous system and boosts learning.

Those ubiquitous wires connecting listeners to you-name-the-sounds from invisible MP3 players -- whether of Bach, or any music -- only hint at music's effect on the soul throughout the ages.
Now a data-driven review by Northwestern University researchers that published in Nature Reviews Neuroscience pulls together converging research from the scientific literature linking musical training to learning that spills over to skills including language, speech, memory, attention and even vocal emotion. The science covered comes from labs all over the world, from scientists of varying scientific philosophies, using a wide range of research methods.

scientists use the term neuroplasticity to describe the brain's ability to adapt and change as a result of training and experience over the course of a person's life. The studies covered in the Northwestern review offer a model of neuroplasticity, Kraus said. 

The research strongly suggests that the neural connections made during musical training also prime the brain for other aspects of human communication.

Nina Kraus, lead author of the Nature perspective, the Hugh Knowles Professor of Communication Sciences and Neurobiology and director of Northwestern's Auditory Neuroscience Laboratory says, A musician's brain selectively enhances information-bearing elements in sound, 

"In a beautiful interrelationship between sensory and cognitive processes, the nervous system makes associations between complex sounds and what they mean." The efficient sound-to-meaning connections are important not only for music but for other aspects of communication, she said.

And musicians trained to hear sounds embedded in a rich network of melodies and harmonies are primed to understand speech in a noisy background. They exhibit both enhanced cognitive and sensory abilities that give them a distinct advantage for processing speech in challenging listening environments compared with non-musicians.

Children with learning disorders are particularly vulnerable to the deleterious effects of background noise, according to the article. "Music training seems to strengthen the same neural processes that often are deficient in individuals with developmental dyslexia or who have difficulty hearing speech in noise."

"The effect of music training suggests that, akin to physical exercise and its impact on body fitness, music is a resource that tones the brain for auditory fitness and thus requires society to re-examine the role of music in shaping individual development, " the researchers conclude.